Discovery & Preclinical

Following the FDA’s September 2026 final rule supporting New Approach Methodologies (NAMs), human-relevant, non-animal testing methods are gaining importance in drug development. This article explores how Ignyte Bio’s antigen-specific T cells can be combined with advanced model systems to evaluate therapeutic activity and potential off-target effects in cell therapy development.

Applied Pathology Systems (APS) is a Massachusetts-based contract research organization providing integrated comprehensive services in vivo pharmacology, preclinical bioanalysis, biomarker analysis, histology, and pathology evaluation as well as study reporting. By connecting in vivo study execution with bioanalytical assays, digital pathology, and expert pathology evaluation, APS helps research teams generate connected datasets from dosing and exposure through tissue-level biological response.

Reliable AAV experiments start with a well-characterized vector. Learn how Vector Biolabs approaches AAV quality and QC to help researchers stay on target from the very start.

Do you prioritize the realistic biology of a primary cell, or the endless consistency of an immortalized cell line? The truth is, it’s not an either/or choice. Dive into Innoprots' latest post to find out which model best fits your specific biological question.

Jubilant Biosys is an integrated CRDMO supporting drug discovery, development, and manufacturing through multidisciplinary scientific teams and connected research infrastructure. They have delivered more than 100 integrated drug discovery programs across therapeutic areas.

This blog was written by Biointron, a CRO specializing in antibody discovery, expression, and optimization services for biotech and pharmaceutical companies. From gene sequence to purified antibodies, production only takes 2 weeks — and with RushData, an AI antibody wet lab validation service, computational predictions become experimentally confirmed candidates at high throughput. They have delivered tens of thousands of recombinant antibodies for more than 3,000 biotech and pharma companies worldwide.

The rising prevalence of metabolic diseases has accelerated research into therapies for obesity, type 2 diabetes, and MASH. This blog post highlights the rapid evolution of incretin-based and next-generation metabolic therapies and discusses how advanced functional assays are helping researchers evaluate promising drug candidates.

This blog was written by Biointron, a CRO specializing in antibody discovery, expression, and optimization services for biotech and pharmaceutical companies. From gene sequence to purified antibodies, production only takes 2 weeks — and with RushData, an AI antibody wet lab validation service, computational predictions become experimentally confirmed candidates at high throughput. They have delivered tens of thousands of recombinant antibodies for more than 3,000 biotech and pharma companies worldwide.

This blog was written by SandboxAQ, who provide a comprehensive, end-to-end drug discovery approach powered by Large Quantitative Models (LQMs) derived from AI and physics. Their advanced process enables faster, more accurate development of small molecules and biologics from early-stage research straight through to clinical candidate selection.

This blog was written by PromoCell, who provide high-quality primary human cells, optimized media, and tailored solutions for reproducible and translational research. Their portfolio enables consistent results across in-house and outsourced workflows.

‍This Tech Snapshot was written by Artis BioSolutions, an end-to-end cell and gene therapy partner providing synthetic DNA starting material, viral vector manufacturing (AAV and LVV), and cell therapy manufacturing under one roof.

In early-stage drug discovery, off-the-shelf reagents don’t always align with unique biological targets or strict project timelines. To better understand how custom workflows can accelerate therapeutic development, we spoke with the Custom Services team at BPS Bioscience about their integrated approach to contract research. In this interview, they share insights into the distinct advantages of direct scientist-to-scientist collaboration, the operational value of a milestone-driven framework, and how their ISO 9001:2015-certified infrastructure ensures full intellectual property protection for biopharmaceutical partners.

This blog post was written by Hologic Diagenode, a leading provider of epigenomics with more than 20 years of expertise in the field. Their

Molecular glues enable targeting of previously undruggable proteins by promoting protein-protein interactions, potentially treating diseases unresponsive to conventional small-molecule drugs through degradation, stabilization, or functional activation mechanisms. Discovery and validation of molecular glues requires comprehensive screening strategies including DNA-encoded libraries and high-throughput assays, followed by in vitro and in vivo testing to confirm binding, selectivity, and therapeutic efficacy.

This installment of Supplier Spotlight® highlights RadMD, a global imaging contract research organization (iCRO) that provides end-to-end imaging support for clinical trials. Their services are available on Scientist.com.

While AI is rapidly advancing drug discovery and development capabilities, the real bottleneck is outdated operational workflows that slow execution and prevent organizations from acting quickly on better decisions. Pharma companies that integrate their end-to-end sourcing and execution processes will gain sustainable competitive advantage by enabling faster decision-making and action across the full R&D pipeline.

Lab technicians in animal research are clinical first responders whose intuitive attachment to animals serves as a diagnostic tool for identifying welfare issues and ensuring research quality. Scientist.com's VERIF.i framework empowers techs to act on their clinical judgment, recognizing that emotional connection and gut instinct, not detached professionalism, are essential for both animal welfare and sound science.

This installment of Supplier Spotlight® highlights MedChemExpress, a leading global supplier of high-quality life science reagents. Their services are available on Scientist.com.

This blog post was written by Crown Bioscience, a global contract research organization (CRO) providing discovery, preclinical and translational...

This blog post was written by BrainXell. An industry-leading producer of neurons and glia advancing neuroscience research and partnering with over...

The FDA has released guidance allowing pharmaceutical developers to reduce or eliminate certain nonclinical testing requirements in non-human primates by shifting toward New Approach Methodologies like computational models and organoids supported by human-relevant data. This paradigm shift promises to lower development costs and timelines while improving animal welfare and accelerating patient access to safer treatments.

This blog post was written by FUJIFILM Corporation, a global contract research organization (CRO) providing drug discovery and preclinical services...

This blog post was written by Applied Pathology Systems (APS). Based in Massachusetts, Applied Pathology Systems (APS) is a premier...

This installment of Supplier Spotlight® highlights Shuimu Biosciences, a definitive force at the dynamic intersection of artificial intelligence and structural biology. They provide a complete, integrated suite of solutions, beginning with featuring the world’s largest commercial platform that delivers stunning atomic-level resolution. Their services are available on Scientist.com.

This blog post was written by Slingshot Biosciences, a biotechnology company based in Emeryville, CA that develops precision-engineered cell mimics™ for cell-based applications in research, diagnostics, and biologics manufacturing. Slingshot’s products are used across the drug-development continuum, from discovery through manufacturing, by many of the world’s 12 out 15 of the top biopharma and 4 of the top 5 diagnostics organizations. Their services are available on Scientist.com.